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The use of porous titanium‐based implant materials for bone contact has been gaining ground in recent years. Selective laser melting (SLM) is a rapid prototyping method by which porous implants with highly defined external dimensions and internal architecture can be produced. The coating of porous implants produced by SLM with ceramic layers based on calcium phosphate (CaP) remains relatively unexplored,...
A novel, sensitive method for quantifying an equivalent antioxidant concentration, specifically vitamin E (VE), in postprocessed ultra‐high molecular weight polyethylene (UHMWPE) for orthopedic implants is presented. This method correlates oxidative‐induction time (OIT) determined from differential scanning calorimetry with starting VE weight percent in solvent blended samples using a nonlinear power...
Within the past two decades polylactic‐co‐glycolic acid (PLGA) has gained considerable attention as a biocompatible and biodegradable polymer that is suitable for tissue engineering and regenerative medicine. In this present study, we have investigated the potential of PLGA, collagen I (ColI), and polyurethane (PU) scaffolds for ligament tissue regeneration. Two different ratios of PLGA (50:50 and...
There is an increased interest in developing adipose tissue for in vitro and in vivo applications. Current two‐dimensional (2D) cell‐culture systems of adipocytes are limited, and new methods to culture adipocytes in three‐dimensional (3D) are warranted as a more life‐like model to study metabolic diseases such as obesity and diabetes. In this study, we have evaluated different porous bacterial nanocellulose...
The insertion of cochlear implants (CIs) often causes fibrous tissue growth around the electrode, which leads to attenuation of function of CIs. Inhibition of fibrosis in vivo using dexamethasone (Dex) released from the implant base material (polydimethylsiloxane [PDMS]) coated with a protein repelling hydrogel (star‐shaped polyethylene glycol prepolymer, sPEG) was, therefore, the aim of the study...
This study evaluated the influence of silica‐based film coatings on the surface of yttrium‐stabilized tetragonal zirconia polycrystal (Y‐TZP), in particular on the durability of the bond strength between the ceramic and resin cement. Eighty Y‐TZP (In‐Ceram YZ, Vita) blocks (4 × 4 × 3 mm) were obtained and divided into four groups according to the surface treatments (n = 20): tribochemical silica coating...
In‐body tissue architecture—a novel and practical regeneration medicine technology—can be used to prepare a completely autologous heart valve, based on the shape of a mold. In this study, a three‐dimensional (3D) printer was used to produce the molds. A 3D printer can easily reproduce the 3D‐shape and size of native heart valves within several processing hours. For a tri‐leaflet, valved conduit with...
ObjectivesTo evaluate whether ultraviolet (UV) light irradiation of smooth and rough zirconia disks enhances its biocompatibility with human gingival fibroblasts (HGFs).
Materials and MethodsZirconia disks were divided into four groups: smooth control (S‐C), smooth with UV light treatment (S‐UV), rough control (R‐C), and rough with UV light treatment (R‐UV). The surface morphology and wettability...
Polyurethane biostability has been the subject of intense research since the failure of polyether polyurethane pacemaker leads in the 1980s. Accelerated in vitro testing has been used to isolate degradation mechanisms and predict clinical performance of biomaterials. However, validation that in vitro methods reproduce in vivo degradation is critical to the selection of appropriate tests. High temperature...
The aim was to compare the osseointegration of grit‐blasted implants with and without a hydrogen fluoride treatment in rat tibia and femur, and to visualize bone formation using state‐of‐the‐art 3D visualization techniques. Grit‐blasted implants were inserted in femur and tibia of 10 Sprague‐Dawley rats (4 implants/rat). Four weeks after insertion, bone implant samples were retrieved. Selected samples...
In this study, dextran‐coated polyvinyl formal (PVF) sponges with high water‐holding capability were developed to increase the osteogenic response in the PVF sponge. The study aimed to estimate the effect of the increased water‐holding capability of the sponges on osteogenic capacity at a bone defect site in the rabbit femur epiphysis. Bone formation was evaluated using radiography, microcomputed...
During the loosening cascade of cemented rough femoral stems, the destruction of the mantle and the production of cement and metal wear debris occur after the loss of constraint at the interface. Two‐dimensional (2D) measurements (light microscopy based morphometry on fragments of mantles and vertical scanning interferometry of femoral stems) permitted mathematical 3D‐extrapolations to estimate the...
Media perfusion is often required to maintain cell viability within topographically complex 3‐dimensional scaffold cultures. Osteoblast‐seeded scaffolds for bone regeneration require robust cell proliferation and survival both within the scaffold and over the exterior for optimal osteogenic capacity. Conventional press‐fitting cassettes ensure internal fluid flow through the scaffold but may restrict...
The porosity of a material can be determined using a diversity of methods; however, the results from these methods have so far not been compared and analyzed for calcium phosphate cements (CPCs). The aim of this study was to compare a fast and easy method for porosity measurements with some commonly used porosity methods for CPCs. The investigated method is based on the assumption that when a wet...
Keratin‐based composite nanofibers have been fabricated by an electrospinning technique. Aqueous soluble keratin extracted from human hair was successfully blended with poly(ε‐caprolactone) (PCL) in different ratios and transformed into nanofibrous membranes. Toward the potential use of this nanofibrous membrane in tissue engineering, its physicochemical properties, such as morphology, mechanical...
Iron oxide nanoparticles (IONPs) have been extensively used for biomedical applications like in the diagnosis and treatment of various diseases, as contrast agents in magnetic resonance imaging, and in targeted drug delivery. Despite several attempts, there is a dearth of information with respect to the cellular response and in‐depth toxicity analysis of the nanoparticles. Considering the potential...
We evaluated the efficacy and outcome of intracordal auricular cartilage injection in patients with unilateral vocal fold paralysis. Our interest developed from findings of a canine model study that reported that histologic characteristics of cartilage were preserved 2 and 3 years after intracordal autologous cartilage injection. Between May 2002 and July 2010, 29 patients with breathy dysphonia caused...
Silk proteins represent a unique choice in the selection of biomaterials that can be used for corneal tissue engineering and regenerative medical applications. We implanted helicoidal multilamellar arginine–glycine–aspartic acid‐functionalized silk biomaterials into the corneal stroma of rabbits, and evaluated its biocompatibility. The corneal tissue was examined after routine hematoxylin–eosin staining,...
Peritendinous fibrotic adhesions after tendon surgery are still a problem up‐to‐date. Approaches to overcome or at least minimize adhesion formation include implantation of barrier materials, application of lubricants or combinations of materials and functionalized drugs that are controllably released and support the healing tendon to glide and achieve the full range of motion after regeneration....
In the present work, new amphiphilic macroporous polymeric adsorbent (AMPA) membranes for LDL‐apheresis were prepared by 60Co γ‐ray irradiation‐induced grafting copolymerization of polypropylene (PP) nonwoven fabric with acrylic acid, followed by bonding cholesterol through linkers of different length. The new AMPA membranes were characterized by attenuated total reflection Fourier transform infrared...
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